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KMID : 0043320140370060721
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Archives of Pharmacal Research
2014 Volume.37 No. 6 p.721 ~ p.727
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Anti-inflammatory and antioxidant activities of phenolic compounds from Desmodium caudatum leaves and stems
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Li Wei
Sun Ya Nan
Yan Xi Tao
Yang Seo-Young
Kim So-Hyun
Chae Doo-Byeong
Hyun Jin-Won
Kang Hee-Kyoung
Koh Young-Sang
Kim Young-Ho
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Abstract
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Four flavanonols (1?4), one xanthone (5), and three flavonoid glycosides (6?8), were isolated from the leaves and stems of Desmodium caudatum. Their structures were elucidated by comparing spectroscopic data with reported values. The anti-inflammatory activity of the isolated compounds was investigated in lipopolysaccharide (LPS)-stimulated bone marrow-derived dendritic cells. Among them, compounds 1 and 2 exhibited inhibitory effects on LPS-induced IL-6, IL-12 p40, and TNF-α production with IC50 values ranging from 6.0 to 29.4 μM. Compound 5 exhibited 1,1-diphenyl-2-picrylhydrazyl radical and intracellular reactive oxygen species scavenging activity in human HaCaT keratinocytes. These results warrant further studies of the potential anti-inflammatory and antioxidant benefits of compounds from D.caudatum.
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KEYWORD
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Desmodium caudatum, Flavonone, Xanthone, Anti-inflammatory, Antioxidant
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